Recombination resistant retroviral helper cell and products...

Details Recombination resistant retroviral helper cell and products... Recombination resistant retroviral helper cell and products...

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/86 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01)

Patent

CA 1329562

Abstract An improved helper cell for growing up stocks of replication incompetent retrovirus vectors is disclosed. The helper cell resists recombination events due to the fact that natural promoters and poly(A) sequences in the helper sequences have been replaced with foreign promoters and poly(A) sequences bearing little or no homology to the vectors. Plasmids containing these modified sequences can still create a helper cell with resulting expression of the needed helper proteins, yet there is much less risk of recombination events in the helper cell. Also disclosed are vectors produced by such helper cells, target cells infected by such vectors, and helper cells which convert vectors so that they can be used with hosts from different species.

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