C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/43, 150/16.5
C12N 5/08 (2006.01) A61K 35/50 (2006.01) C12N 5/00 (2006.01) C12Q 1/24 (2006.01) G01N 33/50 (2006.01)
Patent
CA 1291432
Abstract The present invention discloses a biologically active basement membrane composition. When polymerized under physiological conditions, the composition forms gel-like structures whose ultrastructure resembles interconnected thin sheets of the lamina densa zone of basement membrane. The major components of the composition include laminin, type IV collagen, heparan sulfate proteoglycan, entactin and nidogen. These components polymerize in constant proportions when redissolved and allowed to reconstitute. Molecular sieve studies on the soluble extract demonstate that laminin, entactin and nidogen are associated in a large but dissociable complex. The reconstituted matrix is biologically active and stimulates the growth and differentiation of a variety of cells, including epithelial cells, nerve cells, hair follicles and the like. The reconstituted matrix can also be used for determining metastatic potential of tumor cells and for isolating metastatic tumor cells.
516643
Kleinman Hynda Karen
Martin George Reilly
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
U.s. Departm Ent Of Commerce The United States Of America Represented By The Secretary
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