C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/077 (2010.01) A61K 35/32 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2236807
A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals in vivo. Methods for preparing the biological materials and methods of using the biological materials are described.
Matériau biologique comprenant une couche continue de tissu cartilagineux reconstitué in vitro et contenant des éléments associés à la minéralisation du cartilage. On peut cultiver ce matériau biologique avec un agent minéralisant, afin d'obtenir un matériau biologique minéralisé. Ce matériau biologique minéralisé est caractérisé par le fait qu'il possède une composition biochimique et une organisation physiologique sensiblement similaires aux zones profondes et contiguës de cartilages calcifiés de cartilages articulaires que l'on trouve chez l'animal in vivo. Des procédés de préparation et d'utilisation de ces matériaux biologiques sont également décrits.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mount Sinai Hospital
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