Reconstituted surfactants having improved properties

Details Reconstituted surfactants having improved properties Reconstituted surfactants having improved properties

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 9/00 (2006.01) A61P 11/00 (2006.01)

Patent

CA 2689066

The present invention is directed to a reconstituted surfactant comprising a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide comprising a sequence of repeated units constituted of a number of hydrophobic amino acid residues comprised between 3 and 8 and one basic amino acid residue. The invention is also directed to the pharmaceutical compositions thereof and to its use for the prophylaxis and/or treatment of RDS and other respiratory disorders.

La présente invention porte sur un agent tensioactif reconstitué comprenant un support lipidique, un analogue polypeptidique de la protéine d'agent tensioactif native SP-C, et un polypeptide comprenant une séquence d'unités de répétition constituée d'un certain nombre de résidus d'acide aminé hydrophobe compris entre 3 et 8 et d'un résidu d'acide aminé basique. L'invention porte également sur les compositions pharmaceutiques de celui-ci et sur son utilisation pour la prophylaxie et/ou le traitement du syndrome respiratoire aigu sévère (RDS) et autres troubles respiratoires.

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