Reconstitution medium for protein and peptide formulations

A - Human Necessities – 61 – K

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Details

A61K 47/06 (2006.01) A61K 9/08 (2006.01) A61K 38/16 (2006.01)

Patent

CA 2534565

Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.

La présente invention concerne des compositions convenant à la reconstitution de formulations concentrées contenant des produits pharmaceutiques à base de protéines et/ou de peptides. Cette composition inclut généralement un ou plusieurs lipides, ainsi qu'un ou plusieurs alcools qui favorisent et stabilisent la formation (a) d'ensembles moléculaires lipides avec encapsulation de protéines plus grosses, (b) de complexes lipido-protéiniques, et, (c) de solutions de protéines et de lipides. Ce milieu de reconstitution améliore l'association entre protéines et lipides, ce qui, à son tour, modifie les propriétés pharmaceutiques.

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