Rectal compositions

Details Rectal compositions Rectal compositions

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 9/02 (2006.01)

Patent

CA 2162919

The invention relates to a pharmaceutical composition for rectal administration which comprises 1,2,3,9-tetrahydro-9-methyl-3-[(2- methyl-1H-imidazol-1-yl)-methyl]-4H-cebazol-4-one in the form of its free base or a pharmaceutically acceptable solvate thereof as active ingredient, together with one or more pharmaceutically acceptable carriers or excipients. Methods for the manufacture of such compositions and for their use in the treatment of conditions mediated through the action of 5-hydroxytryptamine at 5-HT3 receptors arc also described.

L'invention se rapporte à une composition pharmaceutique destinée à être administrée par voie rectale, et comprenant, comme principe actif, 1,2,3,9-tétrahydro-9-méthyl-3-¢(2-méthyl-1H-imidazol-1-yl)-méthyl!-4H-carbazol-4-one sous forme de sa base libre ou un solvat pharmaceutiquement acceptable de ce composé, ainsi qu'un ou plusieurs excipients ou véhicules pharmaceutiquement actifs. Des procédés de fabrication de ces compositions sont également décrits, ainsi que des procédés d'utilisation de ces compositions pour traiter des états induits par l'action de la 5-hydroxytryptamine au niveau des récepteurs de 5-HT3.

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