A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/18 (2006.01) A61K 9/00 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 38/42 (2006.01)
Patent
CA 2177066
A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid, and then an outer layer of a sugar or allosteric effector is applied.
L'invention concerne des globules rouges artificiels constitués de particules centrales nanocristallines auxquelles on a fixé un transporteur d'oxygène tel que l'hémoglobine. On prévoit un revêtement d'ancrage pour le transporteur d'oxygène entre la particule centrale nanocristalline et le transporteur d'oxygène, pour assurer une fixation du transporteur d'oxygène aux particules centrales nanocristallines portant le transporteur d'oxygène, sans dénaturer le transporteur d'oxygène ou diminuer d'une quelconque manière son aptitude à transporter l'oxygène. La particule nanocrocristalline centrale portant le transporteur d'oxygène lié reçoit un revêtement lipidique suivi d'une couche externe d'un sucre ou d'un effecteur allostérique.
Gelman Andrew E.
Hnatyszyn H. James
Kossovsky Nir
Smart & Biggar
The Regents Of The University Of California
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