Redirection of cellular immunity by receptor chimeras

Details Redirection of cellular immunity by receptor chimeras Redirection of cellular immunity by receptor chimeras

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 35/12 (2006.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 14/73 (2006.01) C07K 14/735 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2104957

Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.

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