C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 35/14 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) A61P 37/02 (2006.01) C07K 14/73 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2166102
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor- bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
Kolanus Waldemar
Romeo Charles
Seed Brian
Smart & Biggar
The General Hospital Corporation
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