A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/13 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/19 (2006.01) A61K 31/58 (2006.01)
Patent
CA 2212803
A pharmaceutical film matrix comprising nanoparticles of a low solubility drug associated with a steric stabilizer and a film dispersing agent is coated on the surface of carrier particles and overcoated with a protective layer. Pharmaceutical compositions comprising the film matrix-coated carrier exhibit excellent bioavailability, are useful in methods of treating mammals and are extremely stable in that they are capable of being redispersed without extensive agglomeration into larger particles after being stored.
Matrice en couche mince pharmaceutique comprenant des nanoparticules d'un médicament peu soluble associé à un stabilisant stérique, à un agent dispersant la couche mince qui enrobe la surface des particules porteuses et est revêtu d'une couche de protection. Compositions pharmaceutiques comprenant un support enrobé de la matrice en couche mince, présentant une très bonne biodisponibilité, et s'avérant utiles dans des méthodes de traitement de mammifères et très stables puisque capables de se redisperser sans s'agglomérer excessivement en plus grosses particules après stockage.
Desieno Mark A.
Stetsko Gregg
Elan Pharma International Limited
Fetherstonhaugh & Co.
Nanosystems L.l.c.
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