Redox drug derivatives

Details Redox drug derivatives Redox drug derivatives

C - Chemistry, Metallurgy

07

D

C07D 209/46 (2006.01) C07C 237/44 (2006.01) C07D 215/233 (2006.01) C07D 317/28 (2006.01) C07D 405/06 (2006.01) C07D 498/06 (2006.01)

Patent

CA 2762022

The present invention provides redox drug derivatives. In particular, 9-fluoro-2,3- dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4- benzoxazine-6-carboxylic acid, 1-ethyl-6-fluoro-1,4-dihydro-7-(4-methyl-1-piperazinyl)-4- oxo-3-quinolinecarboxylic acid, (3R, 4R, 5S)-4-(acetylamino)-5-amino-3-(1- ethylpropoxy)-1-cyclohexene-1-carboxylic acid ethyl ester, (3S)-3-(aminomethyl)-5- methylhexanoic acid, (3S)-1 -[2-(2,3-dihydro-5-benzofuranyl)ethyl]-a-a-diphenyl-3- pyrrolidineacetamide, (1S,2S,3S,4R)-3-[(1S)-1 -acetamido-2-ethyl-butyl]-4- (diaminomethylideneamino)-2-hydroxy-cyclopentane-1-carboxylic acid and (2R,3R,4S)- 4-[(diaminomethylidene)amino]-3-acetamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4- dihydro-2H-pyran-6-carboxylic acid redox derivatives.

La présente invention porte sur des dérivés redox de médicaments. En particulier, l'invention porte sur des dérivés redox de l'acide 9-fluoro-2,3-dihydro-3-méthyl-10-(4-méthyl-1-pipérazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylique, de l'acide 1-éthyl-6-fluoro-1,4-dihydro-7-(4-méthyl-1-pipérazinyl)-4-oxo-3-quinoléinecarboxylique, de l'ester éthylique de l'acide (3R,4R,5S)-4-(acétylamino)-5-amino-3-(1-éthylpropoxy)-1-cyclohexène-1-carboxylique, de l'acide (3S)-3-(aminométhyl)-5-méthylhexanoïque, du (3S)-1-[2-(2,3-dihydro-5-benzofuranyl)éthyl]-a-a-diphényl-3-pyrrolidineacétamide, de l'acide (1S,2S,3S,4R)-3-[(1S)-1-acétamido-2-éthylbutyl]-4-(diaminométhylidèneamino)-2-hydroxycyclopentane-1-carboxylique et de l'acide (2R,3R,4S)-4-[(diaminométhylidène)amino]-3-acétamido-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyrane-6-carboxylique.

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