Redox systems for brain-targeted drug delivery

Details Redox systems for brain-targeted drug delivery Redox systems for brain-targeted drug delivery

C - Chemistry, Metallurgy

08

B

167/168

C08B 37/16 (2006.01) A61K 9/22 (2006.01) A61K 31/43 (2006.01) A61K 31/44 (2006.01) C07C 219/28 (2006.01) C07C 229/08 (2006.01) C07C 271/16 (2006.01) C07D 211/90 (2006.01) C07D 213/80 (2006.01) C07D 213/82 (2006.01) C07D 223/28 (2006.01) C07D 233/78 (2006.01) C07D 401/12 (2006.01) C07D 473/00 (2006.01) C07D 499/00 (2006.01) C07H 19/06 (2006.01) C07J 43/00 (2006.01) C08B 37/00 (2006.01)

Patent

CA 1331564

ABSTRACT OF THE DISCLOSURE Inclusion complexes of hydroxypropyl, hydroxy- ethyl, glucosyl, maltosyl or maltotriosyl derivatives of .beta.- or .gamma.-cyclodextrin with the reduced, biooxi- dizable, blood-brain barrier penetrating, lipoidal forms of dihydropyridine ? pyridinium salt redox systems for brain-targeted drug delivery provide a means for stabilizing the redox systems, particularly against oxidation. The redox inclusion complexes also provide a means for decreasing initial drug concentra- tions in the lungs after administration of the systems, leading to decreased toxicity. In selected instances, complexation results in substantially improved water solubility of the redox systems as well.

585791

Affiliated with

Also associated with

Rating

Redox systems for brain-targeted drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Redox systems for brain-targeted drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Redox systems for brain-targeted drug delivery will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1281179