Reduced and controlled surface binding of biologically...

Details Reduced and controlled surface binding of biologically... Reduced and controlled surface binding of biologically...

A - Human Necessities

61

L

A61L 33/00 (2006.01) A61K 47/26 (2006.01) A61L 31/10 (2006.01)

Patent

CA 2152379

Articles of manufacture which are adapted for use in contact with one or more biologically active agents are coated with a glassy carbohydrate film. The glassy film provides a reduced surface energy coating which exhibits a reduced degree of binding with biologically active agents. Methods for applying the glassy carbohydrate film are disclosed wherein the glassy film is adsorbed directly onto the article surface. The coated articles are for use both in vitro and in vivo where contact with biologically active agents is expected. The drawing figure is a graph of the adsorption isotherms showing the effectiveness of the present invention in reducing binding of insulin to the surface of borosilicate glass vials.

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