Reduced formate poly(alkylene oxide) for a controlled...

Details Reduced formate poly(alkylene oxide) for a controlled... Reduced formate poly(alkylene oxide) for a controlled...

A - Human Necessities

61

K

A61K 31/765 (2006.01) A61K 9/00 (2006.01) A61K 9/22 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61K 47/34 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2483656

Oral delivery vehicles and compositions for providing sustained release of secondary amines including reboxetine with reduced formate poly(alkylene oxide) polymers are provided. Processes for reducing the amount of the formic compounds from the polymers comprising contacting the polymers with an acid having a Pka lower than that of formic acid are also disclosed.

L'invention concerne des excipients et des compositions à administration par voie orale assurant une libération prolongée d'amines secondaires contenant une reboxetine ayant des polymères de poly(alkylène oxyde) de formate réduits. L'invention concerne des procédés de réduction de la quantité de composés formiques provenant des polymères consistant à mettre en contact les polymères avec un acide ayant un Pka inférieur à celui de l'acide formique.

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