C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/10 (2006.01) A61K 31/495 (2006.01) C07D 213/54 (2006.01)
Patent
CA 2331041
The invention relates to pharmaceutically acceptable salts of 1-(6- chloronaphth-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl]piperazine and reduced particle size forms of either the compound or a pharmaceutically acceptable salt thereof, which possess antithrombotic and anticoagulant properties and accordingly are useful in methods of treatment of humans or animals. The invention also relates to processes for the preparation of pharmaceutically- acceptable salts of the above compound and reduced particle size forms thereof, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments for use in the production of an antithrombotic or anticoagulant effect in humans.
Cette invention a trait à des sels acceptables du point de vue pharmaceutique de 1-(6-chloronapht-2-ylsulfonyl)-4-[4-(4-pyridyl) benzoyl] pipérazine et à des formes à granulométrie réduite de ce composé ou de son sel acceptable du point de vue pharmaceutique, possédant des propriétés antithrombotiques et anticoagulantes, ce qui les rend, par le fait, des plus utiles en thérapie humaine ou animale. Elle concerne également des procédés de production de sels de ce composé, acceptables du point de vue pharmaceutique, et de leurs formes à granulométrie réduite, des compositions pharmaceutiques les contenant ainsi que leur emploi dans la préparation de médicaments à utiliser pour déclencher chez l'homme une action antithrombotique ou anticoagulante
Ashford Marianne
James Roger
Astrazeneca Ab
Smart & Biggar
LandOfFree
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