C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/113 (2010.01) A61K 31/713 (2006.01)
Patent
CA 2743981
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing.
La présente invention concerne des constructions d'ARNi contenant des régions bicaténaires minimales et leur utilisation dans le silençage génique. Les constructions d'ARNi associées à l'invention comprennent une région bicaténaire de 8-14 nucléotides et diverses modifications chimiques, et sont très efficaces en matière de silençage génique.
Cardia James
Kamens Joanne
Khvorova Anastasia
Salomon William
Samarsky Dmitry
Rxi Pharmaceuticals Corporation
Smart & Biggar
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