C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 1/21 (2006.01) C07K 14/36 (2006.01) C12N 15/31 (2006.01) C12N 15/76 (2006.01) C12P 1/04 (2006.01) C12P 21/00 (2006.01)
Patent
CA 2331927
The invention relates to the field of microorganisms and in particular to the culturing of microorganisms. The invention provides means and methods for enhancing the culturing properties of filamentous microorganisms, in particular filamentous fungi. The means and methods according to the invention comprise reducing the branching and/or enhancing the fragmentation of said filamentous microorganisms, whereby their liquid culturing properties are improved. In one embodiment this is achieved by providing said microorganisms with activity capable of enhancing fragmentation and/or reducing branching such as the activity which in e.g. Streptomyces griseus is encoded by ssgA.
L'invention concerne le domaine des micro-organismes et, en particulier, la culture de micro-organismes. Elle concerne des moyens et des procédés servant à améliorer les propriétés de culture de micro-organismes filamenteux, en particulier, des champignons filamenteux. Ces moyens et ces procédés consistent à diminuer la ramification et/ou à augmenter la fragmentation desdits micro-organismes filamenteux, ce qui permet d'améliorer leurs propriétés de culture en milieu liquide. Dans un mode de réalisation, on confère à ces micro-organismes une activité capable d'augmenter la fragmentation et/ou diminuer la ramification, telle qu'une activité qui, dans, par exemple, Streptomyces griseus, est codée par ssgA.
Kraal Barend
Luiten Rudolf Gijsbertus Maria
Van Wezel Gilles Philippus
Borden Ladner Gervais Llp
Nederlandse Organisatie Voor Wetenschappelijk Onderzoek/chemisch
Rijksuniversiteit Te Leiden
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