Reducing chelating agents, their technetium and rhenium...

Details Reducing chelating agents, their technetium and rhenium... Reducing chelating agents, their technetium and rhenium...

C - Chemistry, Metallurgy

07

D

C07D 317/64 (2006.01) A61K 51/04 (2006.01) C07C 217/20 (2006.01) C07C 217/64 (2006.01) C07C 217/84 (2006.01) C07C 323/36 (2006.01) C07C 331/28 (2006.01) C07D 405/12 (2006.01) C07D 407/12 (2006.01) C07D 495/04 (2006.01) C07F 13/00 (2006.01) C07J 41/00 (2006.01) C07K 2/00 (2006.01) C07K 16/00 (2006.01) C07K 16/04 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2048899

Abstract of the Disclosure Compounds of formula I Image (I) are provided, which have the capability of reducing pertechnetate without adding reducing agents to an oxidation state smaller than +7, to form, by groups Y and Z, stable complexes with the thus reduced technetium or rhenium isotopes and to accumulate selectively in certain tissues or lesions, which selectivity is optionally because of a compound coupled through a functional group contained in R1. The technetium and rhenium complexes of the compounds of formula I, as well as their salts with organic and inorganic acids, can be used in in vivo diagnosis and treatment, e.g., in the treatment of tumors.

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