Reducing culling in herd animals growth hormone releasing...

A - Human Necessities – 61 – K

Patent

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A61K 48/00 (2006.01) A61K 38/25 (2006.01)

Patent

CA 2513743

One aspect of the current invention is a method of decreasing an involuntary cull rate in farm animals, wherein the involuntary cull results from infection, disease, morbidity, or mortality. Additionally, milk production, animal welfare, and body condition scores are improved by utilizing methodology that administers the isolated nucleic acid expression construct encoding a GHRH or functional biological equivalent to an animal through a parenteral route of administration. Following a single dose of nucleic acid expression vector, animals are healthier and effects are demonstrated long term without additional administration(s) of the expression construct.

Un aspect de la présente invention concerne un procédé pour réduire un taux de réforme involontaire chez des animaux de ferme, la réforme involontaire résultant d'une infection, d'une maladie, d'une morbidité ou d'une mortalité. De plus, la méthodologie de cette invention permet d'améliorer la production de lait, le bien-être des animaux et la note d'état corporel. Cette méthodologie consiste à administrer à un animal la construction d'expression d'acide nucléique isolée codant une GHRH ou un équivalent fonctionnel biologique, par voie parentérale. L'administration d'une seule dose de vecteur d'expression d'acide nucléique résulte en une meilleure santé des animaux et des effets sont démontrés à long terme, sans qu'une administration supplémentaire de la construction d'expression ne soit nécessaire.

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