C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/06 (2006.01)
Patent
CA 2531595
A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.
L'invention concerne un procédé permettant de réduire la lixiviation de la protéine A lors de la chromatographie d'affinité sur la protéine A, qui consiste à réduire la température ou le pH d'une composition soumise à une chromatographie d'affinité sur la protéine A, ou d'ajouter à ladite composition au moins un inhibiteur de protéase.
Fahrner Robert L.
Laverdiere Amy
Mcdonald Paul J.
O'leary Rhona M.
Genentech Inc.
Smart & Biggar
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