Reducing protein a leaching during protein a affinity...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 16/06 (2006.01)

Patent

CA 2531595

A method for reducing leaching of protein A during protein A affinity chromatography is described which involves reducing temperature or pH of, or by adding one or more protease inhibitors to, a composition that is subjected to protein A affinity chromatography.

L'invention concerne un procédé permettant de réduire la lixiviation de la protéine A lors de la chromatographie d'affinité sur la protéine A, qui consiste à réduire la température ou le pH d'une composition soumise à une chromatographie d'affinité sur la protéine A, ou d'ajouter à ladite composition au moins un inhibiteur de protéase.

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