A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/42 (2006.01) A01N 63/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2625812
A vaginal microbicide including scFv-type antibodies reduces or prevents transepithelial HIV transmission. As the antibodies, anti-CD 18 and/or anti-CD 11 antibodies (of the scFv type) are used. Preferably, anti-ICAM antibody also is used. The antibodies may be delivered to the to-be-protected epithelium using a bacterial delivery system such as a lactobacillus bacterial vehicle. HIV transepithelial transmission can thereby be reduced or prevented, including prevention of initial infection.
Microbicide vaginal à anticorps du type scFv réduisant ou prévenant la transmission transépithéliale du VIH. On utilise comme anticorps les anticorps anti-CD 18 et/ou anti-CD 11 (du type scFv). De préférence, on utilise aussi un anticorps anti-IACM. Les anticorps peuvent être délivrés à l'épithélium à protéger par un système de délivrance bactérien du type véhicule bactérien lactobacille. Ainsi, il est possible de réduire ou de prévenir la transmission transépithéliale du VIH, y compris la prévention de l'infection initiale.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Johns Hopkins School Of Medicine
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