Reduction in complement activation and inflammation during...

A - Human Necessities – 61 – K

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A61K 31/225 (2006.01) A61K 31/341 (2006.01) A61K 31/665 (2006.01) A61P 9/10 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2610502

Administering water-soluble or dispersible synthetic analogs or derivatives of astaxanthin, lutein, zeaxanthin, or lycophyll and/or other carotenoids to a subject may reduce some of the adverse effects of inflammation in a body organ or tissue. The analogs or derivatives may be incorporated into pharmaceutical, over-the-counter, or nutraceutical preparations. Administration of the analogs or derivatives described herein may reduce deposition of inflammatory mediators such as C-reactive protein, complement system proteins or the membrane attack complex (MAC) in tissues. Reduced deposition of these molecules in tissues may reduce cell damage and/or lysis in the tissues.

L'administration d'analogues ou de dérivés synthétiques hydrosolubles ou dispersables d'astaxanthine, de lutéine, de zéaxanthine ou de lycophylle et/ou d'autres caroténoïdes à un sujet peut réduire certains des effets défavorables de l'inflammation dans un organe ou un tissu. Ces analogues ou ces dérivés peuvent être intégrés dans des préparations pharmaceutiques ou nutraceutiques en vente libre. L'administration des analogues ou des dérivés peuvent réduire le dépôt de médiateurs inflammatoires tels que la protéine C réactive, les protéines du système du complément ou le complexe d'attaque membranaire (CAM) dans les tissus. La réduction du dépôt de ces molécules dans les tissus peut réduire les lésions cellulaires et/ou la lyse dans les tissus.

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