Reduction of adhesions using controlled delivery of active...

Details Reduction of adhesions using controlled delivery of active... Reduction of adhesions using controlled delivery of active...

A - Human Necessities

61

K

A61K 38/44 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) A61K 31/275 (2006.01) A61K 31/505 (2006.01) A61K 47/32 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2215317

SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable profileration of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (IP.) bolus and by localized sustained release from a topically applied hydrogel system.

La superoxyde-dismutase (SOD) et d'autres inhibiteurs d'oxygène actif (IOA) sont appliqués directement en combinaison avec une matière barrière dans le site d'une lésion tissulaire pour prévenir ou réduire la formation d'adhérences et la prolifération non souhaitable des cellules. Les matières barrières préférées sont des hydrogels polymériques assurant la libération contrôlée d'IOA et elles sont appliquées directement sur les tissus touchés. Les exemples donnés démontrent les effets de la SOD sur des adhérences pelviennes chez le rat lorsqu'elle est administrée par bolus intrapéritonéal (IP) et par libération prolongée localisée à partir d'un système d'hydrogel d'application topique.

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