Reduction of carbon monoxide interference in gaseous analyte...

G - Physics – 01 – N

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G01N 21/00 (2006.01)

Patent

CA 2625286

Highly sensitive devices for detecting nitric oxide and/or other gaseous analytes in gaseous samples are improved by the incorporation of a carbon monoxide scavenger in the interior of the device or in the device packaging. The release of carbon monoxide within the housing of the device by the plastic used in the construction of the housing or by anything within the device that releases carbon monoxide causes a loss in sensitivity due to competition between the carbon monoxide and the nitric oxide for the binding sites on the device sensor. The scavenger corrects this by either catalyzing the oxidation of carbon monoxide to the less competitive carbon dioxide or immobilizing the carbon monoxide by affinity-type or covalent binding. Analogous effects are achieved for analytes other than nitric oxide but that likewise encounter interference from carbon monoxide in binding to sensors.

Les dispositifs extrêmement sensibles permettant de détecter l~oxyde nitrique et/ou d~autres analytes gazeux dans les échantillons gazeux se trouvent améliorés par l~incorporation d~un décrassant de monoxyde de carbone à l~intérieur du dispositif ou bien dans le conditionnement du dispositif. La libération de monoxyde de carbone dans le logement du dispositif par le plastique utilisé dans la construction du logement ou tout autre élément dans le dispositif qui libère du monoxyde de carbone provoque une perte de sensibilité due à la concurrence entre le monoxyde de carbone et l~oxyde nitrique pour les sites de liaison sur le capteur du dispositif. Le décrassant corrige cet état de fait soit en catalysant l~oxydation du monoxyde de carbone vers le dioxyde de carbone moins compétitif soit en immobilisant le monoxyde de carbone par liaison de type affinité ou liaison covalente. On obtient des effets analogues pour les analytes autres que l~oxyde nitrique mais qui néanmoins peuvent souffrir d~une interférence avec le monoxyde de carbone lors de la liaison avec les capteurs.

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