Reduction of chemical noise in a maldi mass spectrometer by...

Details Reduction of chemical noise in a maldi mass spectrometer by... Reduction of chemical noise in a maldi mass spectrometer by...

B - Operations, Transporting

01

D

B01D 59/44 (2006.01)

Patent

CA 2616722

A MALDI mass spectrometer includes a radiation source, such as a gas or solid state laser, that emits a beam of radiation (typically in the UV or IR wavelengths) directed along the central axis of a linear ion trap in which analyte ions and matrix cluster ions are confined. The radiation beam has a wavelength that is strongly absorbed by the matrix cluster ions. The absorption of radiation by the matrix cluster ions produces dissociation of the matrix cluster ion into fragments having mass-to-charge ratios that lie below a mass-to-charge ratio range of interest. Thus, chemical noise associated with matrix cluster ions is reduced or eliminated.

L~invention concerne un spectromètre de masse MALDI comprenant une source de radiation, telle qu~un laser à l~état solide ou gazeux, qui émet un faisceau de radiation (traditionnellement dans les longueurs d'ondes des UV ou IR) dirigé le long de l'axe central d~un piège à ions linéaire dans lequel des ions d~analytes et des ions d~agrégats matriciels sont confinés. Le faisceau de radiation présente une longueur d~onde qui est fortement absorbée par les ions d~agrégats matriciels. L~absorption d'une radiation par les ions d~agrégats matriciels entraîne une dissociation des ions d~agrégats matriciels en fragments présentant des rapports entre la masse et la charge s~étendant en dessous d~une plage de rapports d~intérêt entre la masse et la charge. Ainsi, le bruit de fond chimique associé aux ions d~agrégats matriciels est réduit ou éliminé.

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