Reduction of infarct volume using citicoline

Details Reduction of infarct volume using citicoline Reduction of infarct volume using citicoline

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/00 (2006.01) A61K 31/505 (2006.01) A61K 31/60 (2006.01) A61K 31/616 (2006.01) A61K 31/66 (2006.01) A61K 31/7068 (2006.01) A61K 38/16 (2006.01) A61K 38/48 (2006.01) A61K 38/49 (2006.01) A61P 7/06 (2006.01) A61P 9/10 (2006.01) C07H 19/10 (2006.01)

Patent

CA 2213000

The invention is directed to a method of reducing the extent of infarction, particularly cerebral infarction subsequent to cerebral ischemia, by the administration of citicoline shortly after an ischemic episode and continuing daily treatment for up to about 30 days, preferably for at least about 6 weeks. The method is useful in the treatment of stroke and severe head trauma patients and maximizes the chances for a full or substantially full recovery of the patient. Combination treatment regimens are also disclosed along with compositions for use therewith.

L'invention concerne un procédé visant à réduire l'ampleur d'un infarctus, notamment d'un infarctus cérébral survenu à la suite d'une ischémie cérébrale, en administrant de la citicoline peu de temps après un accès ischémique et en continuant quotidiennement le traitement pendant jusqu'à environ 30 jours, de préférence pendant au moins 6 semaines environ. Ledit procédé est utile dans le traitement de patients ayant eu un accident vasculaire cérébral ou un traumatisme crânien grave et augmente au maximum les chances que le patient récupère entièrement ou pratiquement entièrement. L'invention décrit également des régimes faisant intervenir des traitements associés ainsi que des compositions à utiliser dans ce cadre.

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