A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/51 (2006.01) A61K 45/06 (2006.01) A61K 49/04 (2006.01) A61K 49/18 (2006.01) A61K 51/12 (2006.01)
Patent
CA 2232879
Disclosed are methods of intravenous administration of nanoparticulate drug formulations to a mammal to avoid adverse hemodynamic effects: by reducing the rate and concentration of the nanoparticles in the formulations; or by pretreating the subject with histamine; or by pretreating the subject with a desensitizing amount of the nanoparticulate drug formulations.
L'invention concerne des procédés d'administration intraveineuse de formulations médicamenteuses nanoparticulaires à un mammifère, permettant d'éviter l'apparition d'effets négatifs hémodynamiques par limitation du taux et de la concentration des nanoparticules dans les formulations, par traitement préalable du sujet à l'histamine, ou par traitement préalable du sujet avec une quantité désensibilisante desdites formulations.
de Garavilla Lawrence
Liversidge Elaine M.
Liversidge Gary G.
Elan Pharma International Limited
Fetherstonhaugh & Co.
Nanosystems L.l.c.
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