Reduction of liposome-induced adverse physiological reactions

Details Reduction of liposome-induced adverse physiological reactions Reduction of liposome-induced adverse physiological reactions

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 47/00 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2160118

Provided herein is a method of administering a liposome composition to an animal, the method involving administering to the animal a liposome composition containing an adverse physiological reaction-reducing effective amount of a liposome which has, in addition to a bioactive agent, a lipid bilayer containing a lipid and a surface agent-modified molecule. An adverse physiological reaction which may be experienced by the animal upon administration of a liposome composition is reduced by way of the presence of the surface agent-modified molecule in the liposome's lipid bilayer.

L'invention concerne un procédé d'administration d'une composition liposomique à un animal, ledit procédé consiste à administrer à l'animal une composition liposomique contenant une dose efficace réduisant des réactions physiologiques indésirables d'un liposome présentant, en plus d'un agent bioactif, une bicouche lipidique contenant un lipide et une molécule modifiée par un agent de surface. La réaction physiologique indésirable que l'animal peut avoir lors de l'administration d'une composition liposomique est réduite par la présence de la molécule modifiée par un agent de surface dans la bicouche lipidique du liposome.

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