Reduction of neurotoxic effects of cytotoxic agents

Details Reduction of neurotoxic effects of cytotoxic agents Reduction of neurotoxic effects of cytotoxic agents

A - Human Necessities

61

K

167/163, 167/209

A61K 47/42 (2006.01) A61K 31/475 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1330422

18 REDUCTION OF NEUROTOXIC EFFECTS OF CYTOTOXIC AGENTS ABSTRACT Intracranial abnormal solid cellular masses, particularly tumors or adjacent tissues that may con- tain tumor cells, are treated by administering to the abnormal area a sufficient amount of a cytotoxic drug comprising a vinca alkaloid dispersed in a stable flow- able proteinaceous matrix. The matrix substantially inhibits the migration of the drug from the site of administration, so as to maintain the primary effect of the drug in the region of administration. Migration can be further inhibited by the use of physiologically acceptable materials which modify cellular properties or physiological responses to further regionalize the placement of drug at the injection site.

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