Reduction of off-target rna interference toxicity

Details Reduction of off-target rna interference toxicity Reduction of off-target rna interference toxicity

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01)

Patent

CA 2691617

The present invention is directed to RNA interference (RNAi) molecules targeted against a nucleic acid sequence, and methods of using these RNAi molecules to reduce off-target toxicity.

L'invention concerne des molécules d'interférence ARN (iARN) ciblées par rapport une séquence d'acide nucléique, et des procédés d'utilisation de ces molécules d'iARN en vue de réduire la toxicité hors cible.

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