Reduction of oxidative stress factors

Details Reduction of oxidative stress factors Reduction of oxidative stress factors

A - Human Necessities

61

K

A61K 35/74 (2006.01)

Patent

CA 2345110

The invention refers to the use of a bacterial strain, preferably of the genus Lactobacillus or Propionibacterium, giving rise to increased amounts of propionic acid in the gut for the manufacture of a medicament for reduction of the level of oxidative stress factors, such as IL-6, reactive oxygen species (ROS), and adhesion molecules in mammals including man. The medicament can be used for the prophylaxis and/or treatment of chronic inflammatory diseases such as rheumatic diseases and psoriasis.

L'invention se rapporte à l'utilisation d'une souche bactérienne, de préférence du genre Lactobacillus ou Propionibacterium, qui permet d'obtenir des quantités de plus en plus importantes d'acide propionique dans l'intestin pour fabriquer un médicament destiné à réduire des facteurs de stress oxydatif tels que IL-6, l'espèce d'oxygène réactif (ROS) et les molécules d'adhérence chez les mammifères, y compris l'homme. Le médicament peut être utilisé à des fins de prévention et/ou de traitement de maladies inflammatoires chroniques telles que les maladies rhumatismales et le psoriasis.

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