C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) A61K 38/17 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) C12Q 1/02 (2006.01) A61K 48/00 (2006.01) C12N 15/12 (2006.01)
Patent
CA 2673531
A method for decreasing cell death in a cell exhibiting aggregation of polyalanine-containing proteins. The method includes introduction of an expression vector to a host cell comprising a nucleotide sequence encoding ubiquilin, followed by maintaining the transformed host cell under biological conditions sufficient for expression and accumulation of the ubiquilin in the host cell, wherein overexpression of ubiquilin reduces sensitivity of cell stress induced by expanded polyalanine proteins.
La présente invention concerne un procédé pour diminuer la mort cellulaire dans une cellule montrant une agrégation de protéines contenant de la polyalanine. Le procédé comprend l'introduction d'un vecteur d'expression dans une cellule hôte comprenant une séquence nucléotidique codant pour l'ubiquiline, suivie du maintien de la cellule hôte transformée dans des conditions biologiques suffisantes pour l'expression et l'accumulation de l'ubiquiline dans la cellule hôte, la surexpression de l'ubiquiline diminuant la sensibilité du stress cellulaire induit par les protéines avec expansion de polyalanine.
Monteiro Mervyn J.
Wang Hongmin
Monteiro Mervyn J.
Smart & Biggar
University Of Maryland - Biotechnology Institute
Wang Hongmin
LandOfFree
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