Reduction of the content of protein contaminants in...

Details Reduction of the content of protein contaminants in... Reduction of the content of protein contaminants in...

C - Chemistry, Metallurgy

07

K

C07K 1/16 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2592054

The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.

La présente invention concerne des compositions protéiques dépendantes de la vitamine K présentant un contenu très faible ou négligeable de contaminants protéiques. La présente invention concerne également un procédé applicable à la préparation de telles compositions protéiques dépendantes de la vitamine K. De tels procédés peuvent être utilisés soit seuls soit en combinaison séquentielle aux fins de réduire le contenu relatif de contaminants protéiques. La présente invention convient particulièrement à la préparation de compositions de facteurs de coagulation choisis entre les polypeptides du facteur X (FX/FXa), les polypeptides du facteur IX (FIX/FIXa), les polypeptides du VII (FVII/FVIIa) et la protéine C anticoagulante, en particulier les polypeptides du facteur VII.

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