Reduction process for the preparation of 4-(hydroxymethyl)...

C - Chemistry – Metallurgy – 07 – D

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C07D 233/64 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1064940

ANDERSON-MENDELSON-WELLMAN CASE 1-2 ABSTRACT An improved process for the preparation of 4-(hydroxymethyl)imidazoles by reducing 4-imidazolecarboxylic acid esters using an alkali metal or calcium in liquid ammonia with an additional proton source provided during the reaction or upon workup.

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