Reductive alkylation of secondary amines with hydrosilane

Details Reductive alkylation of secondary amines with hydrosilane Reductive alkylation of secondary amines with hydrosilane

C - Chemistry, Metallurgy

07

C

C07C 209/28 (2006.01) C07D 233/34 (2006.01) C07D 243/14 (2006.01) C07D 333/64 (2006.01) C07D 403/06 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2359569

A novel process for the production of tertiary amines by reductive alkylation of second amine using hydrosilane and a Lewis acid is disclosed. The novel process has application in the preparationof imidazole-containing benzodiazepines, inhibitors of farnesyl protein transferase.

L'invention concerne un nouveau procédé de production d'amines tertiaires par alkylation réductrice d'amines secondaires au moyen d'hydrosilane et d'un acide de Lewis. Le nouveau procédé peut être utilisé pour la préparation de benzodiazépines contenant de l'imidazole, inhibiteurs de la farnésyl transférase.

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