Reductive cleavage of the exocyclic ester of uk-2a or its...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01)

Patent

CA 2453577

A process comprising reacting compound GF-I with a reducing agent to form compound GF-II wherein Y is selected from the group consisting of H, benzyl, substituted benzyl, CH2OC1-8 alkyl, CH2OC3-8 cycloalkyl, allyl, tetrahydropyranyl, tetra-hydrofuranyl, substituted tetrahydropyranyl, substituted tetra-hydrofuranyl, Si(C1-4 alkyl)3, and Si(Ph)x(C1-4 alkyl)3-x where x is equal to 1, 2 or 3; and wherein said process is conducted: (a) in the presence of a reducing agent; (b) in the presence of an aprotic solvent; and (c) under reaction conditions; is provided. Additionaly, novel compounds produced therefrom are provided.

L'invention concerne un procédé qui comporte la mise en réaction d'un composé GF-I avec un agent réducteur pour former un composé GF-II. Y est sélectionné dans le groupe constitué par H, benzyle, benzyle substitué, alkyle CH¿2?OC¿1-8?, cycloalkyle CH¿2?OC¿3-8?, allyle, tétrahydropyranyle, tétrahydrofuranyle, tétrahydropyranyle substitué, tétrahydrofuranyle substitué, Si(alkyle C¿1-4?)¿3?, et Si(Ph)¿x?(alkyle C¿1-4?)¿3-x?, x étant égal à 1, 2 ou 3. Le procédé est mis en oeuvre : (a) en présence d'un agent réducteur ; (b) en présence d'un solvant aprotique ; et (c) dans des conditions de réaction. L'invention concerne aussi de nouveaux composés produits à l'aide du procédé.

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