Reengineering mrna primary structure for enhanced protein...

Details Reengineering mrna primary structure for enhanced protein... Reengineering mrna primary structure for enhanced protein...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/00 (2006.01)

Patent

CA 2753362

Described herein are rules to modify natural mRNAs or to engineer synthetic mRNAs to increase their translation efficiencies. These rules describe modifications to mRNA coding and 3' UTR sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via AUG or non-canonical initiation codons in coding sequences, and/or 2) by evading miRNA- mediated down-regulation by eliminating one or more miRNA binding sites in coding sequences.

L'invention concerne des règles pour modifier des ARNm naturels ou pour élaborer par ingénierie génétique des ARNm de synthèse pour augmenter leurs rendements de traduction. Ces règles décrivent des modifications à des séquences codantes et 3'UTR de l'ARNm destinées à améliorer la synthèse des protéines par : 1) diminution de la diversion ribosomique par des codons d'initiation AUG ou non canoniques dans des séquences codantes, et/ou 2) en évitant une régulation négative à médiation par un ARNmi par élimination d'un ou plusieurs sites de liaison à l'ARNmi dans des séquences codantes.

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