Refolding of ionic channel proteins

Details Refolding of ionic channel proteins Refolding of ionic channel proteins

C - Chemistry, Metallurgy

07

K

C07K 1/113 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2501836

The invention relates to a method for producing ionic channels or functional sub-units of the same folded in the active structure thereof. According to said method, expressed sub-units of an ionic channel which are solubilised and denatured in a first detergent are provided, and the first detergent is then exchanged for a second detergent which induces folding of the sub-units of an ionic cannel in the native structure thereof. The sub-units of the ionic channel are then assembled in the active structure thereof.

La présente invention concerne un procédé pour produire des canaux ioniques, ou des sous-unités fonctionnelles correspondantes, qui ont une structure active repliée. A cet effet, des sous-unités exprimées d'un canal ionique, qui sont dénaturées ou solubilisées dans un premier détergent, sont tout d'abord mises à disposition, puis le premier détergent est remplacé par un second détergent qui induit un repliement des sous-unités du canal ionique vis-à-vis de leur structure d'origine. Les sous-unités du canal ionique sont ensuite assemblées pour avoir leur structure active.

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