Refolding of polypeptides like recombinant insulin-like...

Details Refolding of polypeptides like recombinant insulin-like... Refolding of polypeptides like recombinant insulin-like...

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) C07K 1/113 (2006.01) C07K 14/475 (2006.01) C07K 14/61 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2168552

A composition is provided comprising about 0.1 to 15 mg/mL of a polypeptide in a buffer having a pH of about 7-12 comprising about 5-40 % (v/v) of an alcoholic or polar aprotic solvent, about 0.2 to 3 M of an alkaline earth, alkali metal, or ammonium salt, about 0.1 to 9 M of a chaotropic agent, and about 0.01 to 15 µM of a copper or manganese salt. The buffer is suitably used in a method for refolding improperly folded polypeptides.

Composition comportant environ 0,1 à 15 mg/ml d'un polypeptide dans un tampon d'un pH d'environ 7 à 12 contenant de 5 à 40 % (v/v) d'un solvant aprotique alcoolique ou polaire, de 0,2 à 3 M d'un sel d'un métal alcalino-terreux, d'un métal alcalin ou d'ammonium, de 0,1 à 9 M d'un agent chaotropique, et de 0,01 à 15 'mu'M d'un sel de cuivre ou de manganèse. Ce tampon joue un rôle actif dans un procédé de repliement de polypeptides mal pliés.

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