Reg-binding protein

Details Reg-binding protein Reg-binding protein

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 45/00 (2006.01) C07K 14/435 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 1/15 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2392514

A protein binding to Reg protein is successfully cloned from cDNA originating in rat Langerhans islet. When expressed on the COS cell surface, this protein specifically binds to Reg protein. When the Reg-binding protein is expressed in RINm5F .beta. cells, DNA synthesis and cell proliferation are stimulated depending on the dose of the Reg protein added to the medium. At a higher concentration, apoptosis is induced. It is considered that the above protein functions as a Reg receptor expressed on the surface of cells such as .beta. cells and regulates the proliferation of these cells. This protein and its gene are useful in developing novel remedies for diabetes.

Cette invention concerne une protéine se liant à la protéine Reg, dont le clonage est obtenu à partir d'un ADNc tiré d'un îlot de Langerhans chez le rat. Exprimée sur la surface de cellule COS, cette protéine se lie spécifiquement à la protéine Reg. Lorsque ladite protéine est exprimée dans des cellules .beta. RINm5F, la synthèse de l'ADN et la prolifération cellulaire se trouvent stimulées en fonction de la dose de protéine Reg ajoutée au support. L'augmentation de la concentration déclenche l'apoptose. On pense que la protéine ci-dessus agit comme un récepteur de Reg exprimé sur la surface de cellules telles que des cellules .beta. et régule la prolifération de ces cellules. Cette protéine et son gène sont utiles pour la mise au point de nouveaux traitements du diabète.

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