Regimens for intra-articular viscosupplementation

Details Regimens for intra-articular viscosupplementation Regimens for intra-articular viscosupplementation

A - Human Necessities

61

K

A61K 31/728 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2590159

The invention provides viscosupplementation methods for treating osteoarthritis and joint injury with HA-based viscosupplements, particularly viscosupplements with an intra-articular residence half-life shorter than 3 weeks. Viscosupplements for use in the methods of the invention may be further characterized in that they contain less than 20 mg/ml HA, at least 5% (w/w) of which is in a gel form, such as, e.g., hylan B. In an illustrative embodiment, hylan G-F 20 (Synvisc~) is administered in a single intra-~articular knee injection of 6 ~ 2 ml.

L'invention concerne des procédés de viscosupplémentation pour le traitement de l'ostéoarthrite et des lésions articulaires par le biais de viscosuppléments à base de hyaluronate de sodium (HA), en particulier des viscosuppléments à demi-vie intra-articulaire inférieure à trois semaines. Les produits en question destinés à être utilisés dans le cadre des procédés décrits peuvent encore être caractérisés par le fait qu'ils contiennent moins de 20 mg/ml de HA, au moins 5 % (w/w) sous forme de gel, par exemple hylane B. Selon une variante, on administre du hylane G-F 20 (Synvisc®) via une seule injection intra-articulaire pour le genou (6 ± 2 ml).

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