G - Physics – 01 – N
Patent
G - Physics
01
N
167/129, 167/139
G01N 33/577 (2006.01) A61K 39/395 (2006.01) C07K 14/78 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/82 (2006.01)
Patent
CA 1198052
ABSTRACT OF THE DISCLOSURE Novel oligopeptides used as reagents or in the preparation of reagents in relation to gamma- carboxyglutamic acid-containing protein of bone. Particularly, labeled oligopeptides and antibodies prepared from immunogen conjugates are disclosed for use in immu- noassays. The oligopeptides of the invention have substan- tially the same amino acid sequence as regions of hBGP. By having oligopeptides that immunogenically mimic regions of BGP antibodies can be obtained that are highly specific for BGP and regions of BGP. Therefore, in conducting immu- noassays, cross reactivity is minimized and a high binding titer is provided. Further as the oligopeptides of the invention are much smaller than the natural hBGP they can be synthesized readily.
426671
Catherwood Bayard D.
Deftos Leonard J.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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