Regioselective liquid phase pegylation

Details Regioselective liquid phase pegylation Regioselective liquid phase pegylation

A - Human Necessities

61

K

A61K 47/48 (2006.01)

Patent

CA 2422707

A method is described for a method for the regioselective liquid-phase pegylation of GRF, which increases the yield of the GRF-PEG conjugate having 1 PEG molecule covalently bound to the e-amino group of Lys12. This method is characterized in that the reaction is carried out in a structuring solvent, such as trifluorethanol.

La présente invention concerne un procédé de pégylation stéréosélective en phase liquide de GRF, qui accroît le rendement du conjugué GRF-PEG dans lequel une molécule PEG est liée de manière covalente au groupe e-amino de Lys?12¿. Ce procédé se caractérise en ce que la réaction est effectuée dans un solvant structurant, tel que le trifluoréthanol.

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