Regioselective substitutions in cyclodextrins

C - Chemistry – Metallurgy – 08 – B

Patent

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C08B 37/16 (2006.01)

Patent

CA 2047726

A process for preparing regiospecifically hydroxyalkylated .alpha.-,.beta.- or .gamma.-cyclodextrins wherein the substitution is either directed toward hydroxyls 2 or 2,3 of the glucose units with little substitution on hydroxyl 6 or toward hydroxyls 6 and with little substitution on the secondary hydroxyls. The regiospecificity is obtained through the proper control of basicity of the reaction mixtures which are comprised of epoxide and cyclodextrins and a suitable solvent.

L'invention concerne un procédé de préparation de cyclodextrines alpha, beta ou gamma hydroxyalcoylées spécifiquement par région, dans lequel la substitution concerne soit des hydroxyles 2 ou 2,3 des unités de glucose, avec peu de substitution sur l'hydroxyle 6, soit des hydroxyles 6 avec peu de substitution dans les hydroxyles secondaires. On obtient la spécificité par région en réglant correctement la basicité des mélanges de réaction, composés d'époxyde ainsi que de cyclodextrines et d'un solvant adapté.

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