Regioselective synthesis of 1,5-diarylpyrazole...

Details Regioselective synthesis of 1,5-diarylpyrazole... Regioselective synthesis of 1,5-diarylpyrazole...

C - Chemistry, Metallurgy

07

D

C07D 231/12 (2006.01) C07C 235/78 (2006.01) C07C 259/06 (2006.01) C07D 307/58 (2006.01)

Patent

CA 2079045

ABSTRACT OF THE DISCLOSURE The invention provides a process for preparing 1,5-diaryl pyrazole anti- inflammatory agents. A 6-aryl-4,6-dioxohexanoic acid is treated with acetic anhydride or acetyl chloride to produce an enol lactone, which is added to methylhydroxylamine to generate the dione hydroxamic acid. This dione hydroxamic acid is then treated with 4-methoxyphenylhydrazine hydrochloride to yield the 1,5-diaryl pyrazole. Novel intermediate compounds in the synthetic pathway are also disclosed.

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