Regioselective synthesis of dtpa derivatives

Details Regioselective synthesis of dtpa derivatives Regioselective synthesis of dtpa derivatives

C - Chemistry, Metallurgy

07

C

C07C 331/28 (2006.01) C07B 53/00 (2006.01)

Patent

CA 2364960

The present invention provides a process for high yield regioselective synthesis of DTPA derivatives that eliminates the need for ion exchange chromatographic separation of intermediates. Moreover, as this process yields a single regioisomer of the chelate, it provides for the regiospecific synthesis of desired chelates useful as radiolabeling agents.

La présente invention concerne un procédé de synthèse stéréosélective à rendement élevé de dérivés de DTPA qui élimine la nécessité de recourir à la séparation chromatographique d'intermédiaires par échange ionique. Par ailleurs, étant donné que ce procédé produit un seul régioisomère du chélate, il permet la synthèse régiosélective de chélates voulus utilisés comme agents radiomarqueurs.

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