Regulatable, catalytically active nucleic acids

Details Regulatable, catalytically active nucleic acids Regulatable, catalytically active nucleic acids

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 9/00 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2412664

Compositions and methods are provided to make, isolate, characterize and use regulatable, catalytically active nucleic acids (RCANA). RCANA may be used for regulating gene expression and in assays to detect the presence of ligands or to detect activation by an effector of an RCANA bound to a solid support such as a chip or multi-well plate. Also disclosed are compositions and methods for automating the selection procedures of the present invention.

L'invention concerne des compositions et des procédés permettant de fabriquer, d'isoler, de caractériser et d'utiliser des acides nucléiques pouvant être régulés et actifs du point de vue catalytique (RCANA). Ces RCANA peuvent être utilisés afin de réguler l'expression génétique et dans des analyses permettant de détecter la présence de ligands ou l'activation par un effecteur d'un RCANA lié à un support solide tel qu'une puce ou une plaque à puits multiples. L'invention concerne également des compositions et des procédés permettant d'automatiser les procédures de sélection de la présente invention.

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