Regulatable fusion promoters

Details Regulatable fusion promoters Regulatable fusion promoters

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A01K 67/027 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2665080

Fusion promoters are described that combine a RNA polymerase III basal promoter and regulatory elements from RNA polymerase II regulatory regions, and which provide specific regulation of expression from the promoter. Such fusion promoters are useful, for example, for expressing RNAi agents in vivo.

L'invention concerne des promoteurs de fusion qui combinent un promoteur basal d'ARN polymérase III et des éléments régulateurs de régions régulatrices d'ARN polymérase II, et qui assurent une régulation spécifique de l'expression à partir du promoteur. Lesdits promoteurs de fusion sont utiles, par exemple, pour exprimer des agents ARNi in vivo.

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