Regulatable retrovirus system for genetic modification of cells

Details Regulatable retrovirus system for genetic modification of cells Regulatable retrovirus system for genetic modification of cells

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/85 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2242381

A novel regulatable retroviral vector in which the v-myc oncogene is driven by a tetracycline-controlled transactivator and a human cytomegalovirus minimal promoter fused to tet operator sequence useful for immortalization of adult neuronal progenitor cells is provided. Producer cell lines which produce high titers of the recombinant retrovirus are also provided.

Dans ce nouveau vecteur rétroviral modulable, l'oncogène v-myc est piloté par un transactivateur commandé par une tétracycline et un promoteur minimal cytomégalovirus humain est fusionné avec la séquence opérationnelle tet servant à immortaliser des cellules mères neuronales adultes. On décrit aussi des lignées cellulaires productrices qui produisent des titres élevés de rétrovirus recombinés.

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