C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01) C12N 5/10 (2006.01) C12P 19/34 (2006.01)
Patent
CA 2432800
Invented is a regulated activation of cell-membrane receptors by small molecule agents. Also invented is a method to render a cell-membrane receptor responsive to the activation by small molecule compounds by specific single point mutations in the transmembrane region.
L'invention concerne l'activation régulée des récepteurs de la membrane cellulaire par des agents à petites molécules. L'invention concerne également une méthode permettant de rendre un récepteur de la membrane cellulaire sensible à l'activation par des composés à petites molécules, au moyen de mutations à point unique spécifiques produites dans la zone transmembranaire.
Delorme Evelyn O.
Duffy Kevin J.
Lamb Peter I.
Luengo Juan I.
Tian Shin-Shay C.
Gowling Lafleur Henderson Llp
Ligand Pharmaceuticals Incorporated
Smithkline Beecham Corporation
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